Induced regeneration—the progress and promise of direct reprogramming for heart repair
نویسندگان
چکیده
منابع مشابه
Small molecules for cell reprogramming and heart repair: progress and perspective.
Regenerative medicine for heart failure seeks to replace lost cardiomyocytes. Chemical approaches for producing ample supplies of cells, such as pluripotent stem cells and cardiomyocytes, hold promise as practical means to achieve safe, facile cell-based therapy for cardiac repair and regenerative medicine. In this review, we describe recent advances in the application of small molecules to imp...
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Heart regeneration for clinical application update 2016: from induced pluripotent stem cells to direct cardiac reprogramming
Cardiovascular disease remains a major cause of death for which current therapeutic regimens are limited. Following myocardial injury, endogenous cardiac fibroblasts, which account for more than half of the cells in the heart, proliferate and synthesize extracellular matrix, leading to fibrosis and heart failure. As terminally differentiated cardiomyocytes have little regenerative capacity foll...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2013
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.3225